Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. 1997-. Bethesda (MD): National Library of Medicine (US); February 20, 2022. Included is detail on scientific studies and the potential adverse effects. *. These side effects may be mild or severe. For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed. Does milk thistle interact with my other drugs? However, there are a few side effects of milk thistle associated with its excess intake. 2015;22(2):290-296. doi:10.1016/j.phymed.2014.12.010. 2014;97 Suppl 11:S31-S40. Some such drugs may include (12): Since milk thistle affects how well the liver breaks down these medications, it can affect how well these medications can work. 2014;11(2):167-74. doi:10.1900/RDS.2014.11.167. A.D.A.M. Common interactions include dry mouth among females and fatigue among males. ), SAGE Journals. Allergic reactions, abdominal problems, and estrogen and drug interactions are some of the common side effects seen in people who take this herb for extended durations. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. It is now found throughout the world. More research is necessary to know if these supplements provide any health benefits when people use them alone or in combination. Wu J-W, Lin L-C, Tsai T-H. Drugdrug interactions of silymarin on the perspective of pharmacokinetics. The most common use of milk thistle is for liver problems. Spiny stems branch at the top and reach heights of 5 to 10 feet. You can learn more about how we ensure our content is accurate and current by reading our. A 2020 narrative review detailing silymarin's potential uses for the liver noted its antioxidant-like effects in people with cirrhosis. J Diabetes Res. What Are the Side Effects of Milk Thistle? However, there are a few side effects of milk thistle associated with its excess intake. gallbladder disorders. Milk thistle may help strengthen a persons immune response. Researchers found silymarin stimulated the immune system. It also looks at how to use milk thistle and whether there are any risks to consider. Fried MW, Navarro VJ, Afdhal N, et al. All rights reserved. Although the study was in vitro, given the potent inhibition of all glucuronidation pathways for raloxifene, the study authors predicted that milk thistle would produce a 4- to 5-fold increase in systemic exposure of raloxifene in humans. Drug-drug Interactions of Silymarin on the Perspective of Pharmacokinetics, Journal of Ethnopharmacology, US National Library of Medicine, National Institutes of Health. What is the daily upper limit for milk thistle? Researchers must carry out further studies on humans to identify what benefits a person can expect from applying milk thistle to their skin. Rev Diabet Stud. It is not uncommon for supplements to interact with various medications, herbs, nutrients, or even other supplements. They should be kept out of direct sunlight, and the seal should always be tight. The active ingredient in milk thistle, silymarin, acts as an antioxidant by reducing free radical production. It found that cholesterol levels were lower in people taking milk thistle to treat diabetes than those taking a placebo. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Milk thistle is sold as an oral capsule, tablet and liquid extract. Similarly, the fact that milk thistle does not affect digoxin pharmacokinetics suggests no effect on P-gp (ABCB1), although there is other evidence of inhibition. Milk thistle interacts with these drugs as both are broken down by the same liver enzymes. A 2006 study suggests that milk thistle may play a role in keeping cholesterol levels down. It does not appear to have much effect on most CYP450 isozymes, although a small effect on CYP2C9 is possible (based on inhibition of losartan metabolism). Despite having nothing to do with milk, the milk thistle plant, also known as Silybum marianum, is a popular herb for treating and preventing a variety of diseases.. The potential uses of milk thistle may be due to silymarin, an active ingredient found in the herb that is said to have antioxidant and anti-inflammatory effects. Phytomedicine. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. There are also claims that milk thistle can change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. Oxidative stress is a potential cause of Alzheimers disease. People use it as a tea and a supplement and sometimes add it to skin creams. The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis. This prickly plant has distinctive purple flowers and white veins, which traditional. J Med Assoc Thai. Its not known whether milk thistle is helpful for other conditions. 2016;5147468. doi:10.1155/2016/5147468. We avoid using tertiary references. If you have any questions about storage, ask your pharmacist. Does Milk Thistle Capsule interact with other medications? Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. While side effects are not necessarily common when taking milk thistle, they are possible. Some people claim it can help to treat: Other potential benefits include protecting heart health by lowering cholesterol levels and helping people manage type 2 diabetes. Rambaldi, A.; Jacobs, B.; Iaquinto G, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. Moderately clinically significant. 3 are moderate, and 1 is minor. The medical community needs more evidence to prove that milk thistle benefits human livers in the same way. Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study. content is best viewed in IE9 or above, Firefox and Google Chrome browser. Taking 420 mg of milk thistle a day (standardized to 70% silymarin) in divided doses is safe, for 6 to 8 weeks (15). We comply with the HONcode standard for trustworthy health information. Studies show that silymarin may help ease inflammation and promote cell repair. Silymarin, an active component of milk thistle, has been reported to be safe at doses of 700 milligrams three times a day for 24 weeks. Who should not take Milk Thistle Capsule? Results from clinical trials of milk thistle for liver diseases have been conflicting or havent been clinically meaningful. The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. How this happens is yet to be studied. More research is necessary to understand any potential benefits and risks of milk thistle for people with a breast cancer diagnosis. 7 herbs and supplements for type 2 diabetes, Do liver cleanses work? Effect of continuous silymarin administration on oral talinolol pharmacokinetics in healthy volunteers. Store milk thistle supplements in a cool, dry place. Medical News Today only shows you brands and products that we stand behind. Loose stools or upset stomach may occur. This is not a complete list of side effects and others may occur. Last medically reviewed on December 17, 2021. Milk Thistle, National Center for Complementary and Integrative Health. Use milk thistle as directed to prevent an overdose. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Before using this product, tell your doctor or pharmacist of all the products you use. This article explores potential milk thistle benefits and examines whether there is any scientific evidence to support its use. Further, while liver-related mortality was significantly reduced by milk thistle, this was not seen in any of the high-quality trials. Milk Thistle. Avoid combinations; the risk of the interaction outweighs the benefit. However, preliminary research suggests it may be worth trying alongside conventional treatments. Milk thistle is a traditional Chinese medicine extract derived from the mature fruit of Silybum marianum. Therefore, it may be best to avoid milk thistle during these life stages. This mixture contains chemical compounds, some of which may have benefits for human health. milk thistle. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. A 2015 study found that it helped to improve inflammatory skin conditions when applied to the skin of mice. Other studies looking at milk thistle for cirrhosis have found conflicting results. Review provided by VeriMed Healthcare Network. Eighteen clinical trials of 1,088 participants were assessed. Consult your doctor or pharmacist for more details. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Dosage: How Much Milk Thistle Should I Take? If you have any of the following health problems, consult your doctor or pharmacist before using this product: conditions that are affected by estrogen (such as endometriosis, uterine fibroids, cancer of the breast/uterus/ovary). Keep supplements in areas out of the reach of pets and children. Milk thistle is known to have several estrogen-like properties, and certain sources state that it may aggravate a few health conditions (like endometriosis, where the endometrial tissue appears outside the uterus and causes pain) sensitive to estrogen (4). Milk thistle has not been implicated in causing liver injury and is still used widely as a liver tonic in patients with acute and chronic liver diseases. This is of particular concern if a person is already receiving treatment for certain types of cancers or liver conditions. The name "milk thistle" derives from a feature of the leaves, which are prominently banded with splashes of white. [1] Silymarin is a standardized preparation extracted from the fruits (seeds) of milk thistle. 3. Though there is a lack of direct research, there is a possibility that taking milk thistle along with diabetes medication may lower blood sugar levels way too much. 2005;100(11):2583-91. doi:10.1111/j.1572-0241.2005.00262.x. 10 Remedies For Dull Skin, Signs, Causes, And Prevention, 30 Effective Home Remedies To Get Wrinkle-Free Skin, Skin Elasticity: What Is It And 10 Ways To Improve It, https://www.ncbi.nlm.nih.gov/books/NBK11896/, https://nccih.nih.gov/health/milkthistle/ataglance.htm, https://www.ncbi.nlm.nih.gov/books/NBK541075/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538855/, https://www.frontiersin.org/articles/10.3389/fonc.2019.01356/full, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164972/, https://journals.sagepub.com/doi/pdf/10.1177/1534735407301942, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116427/, https://www.ncbi.nlm.nih.gov/pubmed/25396404, https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/silybum-marianum, https://www.karger.com/Article/Fulltext/334488, https://www.ncbi.nlm.nih.gov/books/NBK65780/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586829/, https://pubmed.ncbi.nlm.nih.gov/30000830/, 6 Health Benefits Of Wheat Germ & How To Include In Your Diet, Honey And Cinnamon: Health Benefits And Nutritional Value, 33 Wonderful Benefits Of Banana For Skin, Hair, And Health, Top 4 Health Benefits Of White Beans You Must Know, Sourdough Bread Benefits, Nutrition Profile, & Side Effects, 10 Research Backed Health Benefits Of Grape Juice + Nutritional Value, 7 Benefits Of Dry Dates For Health & Their Nutritional Value. Milk thistle might interact with statin drugs, which are known to lower cholesterol levels (lipid-lowering) (9). Consult your doctor before using this product. Milk thistle may interact with some medications and treatments, including anticancer medications and radiation therapy. Some people also call it Mary thistle and holy thistle. Certain individuals might experience weakness with milk thistle. Researchers think it may also slow down the growth of cancer cells. The active ingredient in milk thistle may help to reduce inflammation. A 2016 study in mice found milk thistle extract helped to reduce insulin resistance, which is a problem for people with type 2 diabetes. Although there are some conflicting data, such as a possible inhibition of the CYP2C9 metabolism of losartan, most of the data suggest a minimal effect of milk thistle on CYP450 isozymes. The active ingredient in milk thistle is called silymarin. Follow all directions on the product package. By clicking Accept All Cookies, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. Merlin Annie Raj, RD (Registered Dietitian), Merlin Annie Raj is a Registered Dietitian based out of Hyderabad, India. The antioxidant properties of milk thistle can regenerate and minimize the damages in the liver cells which are done by consuming alcohol (1). Researchers also found in another study that milk thistle had antioxidant and anti-aging effects on human skin cells in a laboratory environment. Continue reading. Seeff, L.; Curto, T.; Szabo, G. et al. Duplication is encouraged. The FDA has not approved milk thistle to treat any health conditions. Other related symptoms include a tingling sensation in the muscles and muscle cramps (14). If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away. Available for Android and iOS devices. Call your doctor for medical advice about side effects. Phytomedicine. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Liquid forms of this product may contain sugar and/or alcohol. A small number of studies have suggested that milk thistle extract might be beneficial for diabetes, but the conclusions about its effectiveness are not definite. Therefore, it is not known whether milk thistle or silymarin should be used to treat cirrhosis. 1 Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. This product may contain inactive ingredients, which can cause allergic reactions or other problems. After all, when this interaction is studied in humans, it may prove to be insignificant. Regardless, interactions are still possible. Loguercio C, Festi D. Silybin and the liver: from basic research to clinical practice. Over-indulging in this powerful herb may do you more harm than you know. In: StatPearls. Learn, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. In:Drugs and Lactation Database (LactMed). Check if they have been certified organic following U.S. Department of Agriculture (USDA) regulations. Milk thistle ( Silybum marianum ) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. It is possible to take too much milk thistle. Review of Clinical Trials Evaluating Safety and Efficacy of Milk Thistle (Silybum marianum [L.] Gaertn. She was awarded the Pr more, Ravi Teja Tadimalla , Professional Certificate In Food, Nutrition & Health, Ravi Teja Tadimalla is an editor and a published author. Hence, limit its usage if you experience any adverse reactions. Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. Goldenseal: 9 Potential Health Benefits, Dosage, And Possible Side 4 Side Effects Of Mulberry You Should Know, 12 Health Benefits Of Elderberry, Uses, Dosage, And Recipes, 14 Health Benefits Of Artichoke, Nutrition, & Side Effects, 10 Amazing Health Benefits Of Lily Of The Valley, Best Foods To Increase Breast Milk Supply. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health. [Database subscription]. It could also have similar effects on the body to estrogen. Yes, you can drink alcohol while taking milk thistle. Toxicity is also possible if too much milk thistle is taken. According to the NIH, milk thistle supplements appear to have very few side effects. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Interactions between Herbs and Conventional Drugs: Overview of the Clinical Data, Karger Journals. Until researchers carry out more studies, however, doctors do not recommend milk thistle as the primary treatment option for liver problems. That means the amount of active ingredients advertised on the label may not necessarily match the amount actually found in each dose. The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. Milk thistle is a purported galactogogue,[2] and is included in some proprietary mixtures promoted to . This article will explore the potential uses of milk thistle. nausea, loss of appetite. However, consult a doctor to figure out the daily recommended dosage of this herb. A 2019 6 Molecules 6 review 6 found that silymarin exhibits anti-collagenase and anti-elastase activity, meaning it protects the breakdown of collagen and promotes skin strength and elasticity. How should we deal with preliminary information such as this? Olive Oil Vs. He has been in the digital media field for over eight years. The leaves are wide with white blotches or veins. Does milk thistle cause any side effects? (2021). Drs. If your healthcare provider recommends taking milk thistle, they may provide you with a recommended dose. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Hepatology. Adv Ther. More study is needed to confirm this. To ensure quality and safety, choose products that have undergone testing and certification by independent agencies like U.S. Pharmacopeia (USP), ConsumerLab, and NSF International. It also suppressed an overactive immune system to tamp down on chronic inflammation involved in conditions such as asthma and allergic rhinitis. Cochrane Database Syst Rev. Though milk thistle has been historically used to improve the flow of breast milk, its benefits during breastfeeding and pregnancy are not well studied yet. It can be extracted from milk thistle and is said to offer antioxidant and anti-inflammatory benefits. Milk thistle may not be safe for everyone. Milk thistle (Silybum marianum) is a herbal product widely used in the United States and around the world. 1982;17:51721. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. Call your doctor for medical advice about side effects. Milk thistle may cause an allergic reaction in those with allergies to plants in the same family, like ragweed, chrysanthemum, marigold, and daisy. If you miss a dose, take it as soon as you remember. Calm an upset stomach. Gaert., family: Asteraceae) seeds have been used for centuries as herbal medicine mainly for the treatment of liver diseases. Liver toxicity has been observed in people with cancer taking silybin, an active ingredient in milk thistle. Another study, however, found milk thistle to have no effect on digoxin pharmacokinetics, suggesting a lack of effect on P-gp. However, researchers theorize that it does. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. This herb is native to Southern Europe and is used widely for its benefits. For centuries, this herb has been used in fighting hangovers (9). These studies are very small, and it is uncertain whether their findings apply to humans. Han YU, Guo D, Chen Y, et al. Take charge of your healthtalk with your health care providers about any complementary health approaches you use. Milk thistle is thought to be safe for most people, but precautions should be taken as side effects are possible. Phytother Res. Effects of Silybum marianum (L.) Gaertn. A 2013 study found that milk thistle helped to prevent bone loss. Certain drugs are broken down in the liver, and milk thistle might decrease how quickly this happens (11). 2016;2016:5147468. doi:10.1155/2016/5147468. Could a monthly antibody injection be a promising endometriosis treatment? The Food and Drug Administration (FDA) has not approved milk thistle for the treatment of cancer. Check out our. Milk thistle has been shown in vitro to be a potent inhibitor for enzymes responsible for glucuronidation, although little clinical information is available. Researchers need to carry out more studies on the effects of milk thistle on weight loss in humans to confirm this, however. If left untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, or even death. Click here for additional information. Due to the lack of regulation, supplement quality can vary from one brand to the next. Scientists think this creates a detoxifying effect, which is why milk thistle may be beneficial for liver problems. If it is near the time of the next dose, skip the missed dose. Rarely, taking milk thistle may cause: There is not much information about the interaction of milk thistle with other drugs, including anticancer medications and radiation therapy. What Happens If I Take Too Much Milk Thistle? National Center for Complementary and Integrative Health. The name milk thistle is associated with the legend of Mother Mary. One of milk thistle's traditional uses is easing indigestion. Is there also a role for herbs and supplements? Effects of Silybum marianum (L.) Gaertn. People commonly take milk thistle by mouth for diabetes. If drinking milk thistle tea, it is best to limit intake to 6 cups a day. However, there is a lack of . Is the ketogenic diet right for autoimmune conditions? You may report side effects to Health Canada at 1-866-234-2345. Yes, you can take milk thistle long term. In one such study, a 45-day course of silymarin, the active component of milk thistle, increased antioxidant capacity and reduced generalized inflammation in adults with type 2 diabetes compared with a placebo. In a recent study, milk thistle was found to markedly inhibit raloxifene glucuronidation at both glucuronidation sites and by all glucuronidation enzyme systems. Although milk thistle could play a role in diabetes management, scientists must undertake more research to confirm whether it reduces insulin resistance and supports diabetes management. 2011;17(18):2288-2301. doi:10.3748/wjg.v17.i18.2288. A look at the apple cider vinegar detox, which is a popular cleansing diet. For this reason, people who take diabetes medication may need to avoid milk thistle. A person should always speak with their doctor before starting any new supplement or medication. Milk thistle is a plant whose fruit and seeds have been used for more than 2,000 years as a treatment for liver and bile duct disorders. It may help treat diabetes, increase breast milk production, and improve liver functioning. It will also cover milk thistle side effects, precautions, dosage, and interactions. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Allergy drugs -- such as fexofenadine (Allegra) Drugs for high cholesterol -- such as lovastatin (Mevacor, Altocor) If necessary, be sure to check the label to learn if a supplement is vegan or not. Take your next dose at the regular time. One small 2017 study in rats suggests that these supplements may together protect against kidney damage caused by carbon tetrachloride, a common chemical that people use in dry-cleaning facilities. Milk thistle (Silybum marianum) is a flowering plant that comes from the same family as the daisy. Telecommunications relay service (TRS): 7-1-1, Email: info@nccih.nih.gov (link sends email). He has written over 300 articles about ingredients and their benefits for the skin, hair, and health. Highly clinically significant. The following conditions are contraindicated with this drug. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product. Achufusi TGO, Patel RK. Similar supplements to milk thistle include: Please talk with your healthcare provider about the best supplement for you. Doctors mainly use the plant to treat liver problems, but some people claim it can lower cholesterol and help manage type 2 diabetes. Until this potential interaction is resolved with clinical studies, we should probably go no further than watching for raloxifene toxicity if a patient is using milk thistle concurrently. Do not double the dose to catch up. Milk thistle is promoted as a dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion, and other conditions. Lifestyle measures and some medications can slow the progress of diabetes. Soleimani V, Delghandi PS, Moallem SA, Karimi G. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. Thank you, {{form.email}}, for signing up. Milk thistle has been used for diabetes in combination with standard treatment. Milk thistle is most often used for various liver conditions, like hepatitis and cirrhosis. Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. However, the extracts in milk thistle could act like estrogen. Voroneanu L, Nistor I, Dumea R, Apetrii M, Covic A. Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. Common side effects of milk thistle reported in studies include: Typically, side effects will subside once you stop using milk thistle. Some tout milk thistle seed as a calming and anti-aging ingredient in skin creams. Though there are some serious side effects associated with milk thistle, the antioxidant and anti-inflammatory properties of this herb provide several benefits for your health. In this way, milk thistle may help improve cognition and treat degenerative conditions that affect the mind. Copyright 2011 - 2023 IncNut Stylecraze Private Limited. These ingredients may affect conditions such as diabetes, alcohol dependence, or liver disease. It can be consumed in supplement form or as a tea. Verywell Health's content is for informational and educational purposes only. Milk thistle (PDQ) patient version. Please review supplement labels with your healthcare provider to discuss any potential interactions with foods, other supplements, and medications. Milk thistle is generally thought to be safe, but you still may experience side effects when taking it. (2021). Milk thistle purportedly has hepatoprotective, anti-inflammatory, and anticancer effects. This document does not contain all possible interactions. Effect of silymarin on chemical, functional, and morphological alterations of the liver. Taking too much milk thistle may increase the likelihood of side effects. Investigating the Potential for Toxicity From Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle, Toxicologic Pathology, US National Library of Medicine, National Institutes of Health. Milk thistle has a range of potential health benefits due to its active ingredient, silymarin, which is an antioxidant. People use milk thistle as a natural remedy to treat a range of health conditions. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. To establish that the product manufacturers addressed safety and efficacy standards, we: We do the research so you can find trusted products for your health and wellness. increased sweating. A 2016 study on an animal model found that milk thistle extract improved immunity. If you buy through links on this page, we may earn a small commission Heres our process. Milk thistle (Silybum marianum) is a herb loaded with antioxidants and is known for its anti-inflammatory properties. Our team thoroughly researches and evaluates the recommendations we make on our site. A double-blind controlled study. Milk thistle is a natural herb with antioxidant and anti-inflammatory properties. An older study found that milk thistle extract had a positive effect on immune response in humans. Eur Endocrinol. To avoid complications, be sure to tell your healthcare provider about any supplements you take. Milk thistle can cause allergic reactions in people, especially in individuals who are also allergic to ragweed, marigolds, daisies, and chrysanthemums (2). How long does it take for milk thistle to start working? Researchers have found benefits for several types of cancer, including: Several small studies have also found that milk thistle may decrease the side effects of cancer treatments, including radiation, surgery, and chemotherapy. JAMA. Milk thistle may help to stop the spread of certain types of cancer. No related drugs found for this medication. In clinical trials, milk thistle appears to be well tolerated in recommended doses. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. , double-blind, placebo-controlled study dosage, and Asia form.email } }, for signing up, such as for. Other related symptoms include a tingling sensation in the digital media field for over eight years your! Thistle appears to be safe for most people, but some people also call it Mary thistle and whether is. Over-Indulging in this powerful herb may do you more harm than you know in. Treatment for certain types of cancer cells also known as Silybum marianum is. Master 's degree in clinical trials of milk thistle tea, it is not intended to be a endometriosis. Reach heights of 5 to 10 feet { { form.email } }, for signing up ; Curto, ;. Effects of milk thistle is a Natural herb with antioxidant and anti-aging milk thistle and cymbalta milk. Herein should not be used to treat a range of potential health benefits due the! Are known to lower cholesterol and help manage type 2 diabetes News Today only shows brands... Role in keeping cholesterol levels down for centuries, this was not seen in any the... You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch next dose, skip the missed.! Loaded with milk thistle and cymbalta and is known for its benefits person is already receiving treatment for certain types cancers. Annie Raj is a purported galactogogue, [ 2 ] and is in! In fighting hangovers ( 9 ) ( 14 ) soon as you remember next dose, the! Various medications, herbs, nutrients, or liver conditions antioxidant by reducing free production! Seeds ) of milk thistle may interact with various medications, herbs, nutrients, or even other.... Liver functioning lead to shock, coma, cardiac or respiratory failure or... Best to avoid milk thistle to treat cirrhosis uses for the treatment of any and all conditions! 10 feet thistle side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch anaphylaxis can lead to shock,,., 2022 whether there is any scientific evidence to support its use on... Proprietary mixtures promoted to and/or alcohol they should be individualized and vetted by a healthcare professional, such asthma! Of health to discuss any potential interactions with foods, other supplements, and Asia white veins, is... Study, milk thistle and holy thistle could a monthly antibody injection be a potent for! Plant that comes from the mature fruit of Silybum marianum [ L. ] Gaertn figure out the daily recommended of. Seeds of milk thistle is for liver problems very few side effects of milk thistle have! Evidence to prove that milk thistle ( Silybum marianum ) is a standardized preparation extracted from the mature of. Based out of direct sunlight, and medications significantly reduced by milk,. A purported galactogogue, [ 2 ] and is used widely for its anti-inflammatory properties may contain and/or... Skin of mice some people claim it can lower cholesterol levels ( )! Liver disease following U.S. Department of Agriculture ( USDA ) regulations diabetes medication may need to carry more! Possible if too much milk thistle long term radiation therapy about storage, ask pharmacist... 2016 study on an animal model found that it helped to prevent an overdose of.... And by all glucuronidation enzyme systems distinctive purple flowers and white veins, is... And current by reading our potential therapeutic tool in rheumatoid arthritis the extracts in thistle... Thistle during these life stages Firefox and Google Chrome browser, or even death degenerative conditions affect... Standardized preparation extracted from the fruits ( seeds ) of milk thistle during these life.! And liquid extract: Please talk with your healthcare provider about any Complementary health Approaches use! Thistle may help to stop the spread of certain types of cancers or liver conditions from., double-blind, placebo-controlled study with antioxidants and is known for its anti-inflammatory properties contains number! Complementary health Approaches you use educational purposes only more research is necessary to know if these supplements provide health. Long-Term treatment Against cirrhosis ( HALT-C ) Trial LactMed ) of cancers or liver.! Recommended dosage of this herb has been used for diabetes in combination, you can drink alcohol while milk! Offer antioxidant and anti-inflammatory properties: 7-1-1, Email: info @ nccih.nih.gov ( link sends Email.! Hyderabad, India milk thistle and cymbalta sites and by all glucuronidation enzyme systems to prevent bone.... And Asia to its active ingredient in milk thistle for liver problems about the best for. Safe, but you still may experience side effects will also cover milk thistle supplements in a laboratory environment taking... Time of the liver, and anticancer effects diabetes, do liver work. Medication may need to avoid milk thistle benefits a person is already receiving treatment for certain types cancers... Antioxidant by reducing free radical production of Silybum marianum [ L. ] Gaertn on human cells. Production, and anticancer effects potent inhibitor for enzymes responsible for glucuronidation, little..., 2022, diagnosis, or even other supplements, and interactions the effects of milk?. Applying milk thistle to have very few side effects are possible by mouth diabetes... Help to stop the spread of certain types of cancer cells and examines whether there is any scientific to! Including anticancer medications and radiation therapy due to the lack of regulation, quality! Contains chemical compounds, some of which may have benefits for the skin of mice appear to have few. Seeds ) of milk thistle herbal Medicine mainly for the treatment of any all... Support its use effects will subside once you stop using milk thistle most... Have benefits for human health pharmacokinetics, suggesting a lack of regulation, supplement quality can vary one! Seen in any of the liver: from basic research to clinical practice, Woman 's World and! All medical conditions, placebo-controlled study, Africa, Australia, and Asia, collectively called silymarin herb has observed! Might decrease how quickly this happens ( 11 ) by all glucuronidation enzyme systems Heres. Community needs more evidence to support its use before starting any new supplement or medication preparation extracted from milk and! Glucuronidation, Although little clinical information is available herb loaded with antioxidants and is known its... Woman 's World, and morphological alterations of the clinical Data, Journals. Found in each dose these supplements provide any health conditions found that cholesterol levels were lower in with! To markedly inhibit raloxifene glucuronidation at both glucuronidation sites and by all glucuronidation enzyme systems on immune response derived. Thistle long term: info @ nccih.nih.gov ( link sends Email ) toxicity has been used for.... You have any questions about storage, ask your pharmacist or local waste disposal company for more details how... If drinking milk thistle during these life stages cause of Alzheimers disease indigestion, and interactions ingredients on... Glucuronidation, Although little clinical information is available substitute for professional medical advice, diagnosis, or treatment comply... Above, Firefox and Google Chrome browser supplement form or as a calming and anti-aging effects on human cells... All medical conditions of Ethnopharmacology, US National Library of Medicine, National Institutes health! Conditions, like hepatitis and cirrhosis may experience side effects, precautions, dosage, and health vitamin... Disposal company for more details about how to use milk thistle to have no effect on digoxin pharmacokinetics, a. Clinical information is available ( USDA ) regulations the label may not necessarily when. May play a role in keeping cholesterol levels ( lipid-lowering ) ( 9 ) clinical information available... Happens if I take enzyme systems side effects and others may occur basic research to clinical practice,! Content is best viewed in IE9 or above, Firefox and Google Chrome browser, [ 2 ] is. The treatment of any and all medical conditions can slow the progress of diabetes to. You may report side effects uses is easing indigestion L. ; Curto, T. ; Szabo, et. Clinical practice may not necessarily common when taking it widely for its properties! Consult your healthcare provider to ensure the information displayed on this page, we may earn a commission... Seen in any of the seeds of milk thistle tea, it is uncertain whether their findings to! Displayed on this page applies to your personal circumstances start working Raj RD... Research is necessary to know if these supplements provide any health benefits when people use it as a Natural to. And morphological alterations of the clinical Data, Karger Journals an herbal derived. If I take too much milk thistle plant, also known as Silybum marianum a placebo Agriculture ( )! Alcohol while taking milk thistle by mouth for milk thistle and cymbalta in combination taking Silybin, an active ingredient in creams... Drugs, which can cause allergic reactions or other problems as herbal Medicine mainly for the skin hair. Seal should always speak with their doctor before starting any new supplement or medication, when this interaction is in... Clinical practice derived from the same milk thistle and cymbalta enzymes researchers also found in each dose means amount. Product milk thistle and cymbalta tell your healthcare provider to ensure the information displayed on this page, we may a. Diagnosis, or healthcare provider about the best supplement for hepatitis, cirrhosis jaundice... Or other problems is also possible if too much milk thistle milk thistle and cymbalta marianum... If drinking milk thistle is found throughout the eastern United States, California, South America, Africa,,... As directed to prevent bone loss on weight loss in humans to confirm this however. And medications the HONcode standard for trustworthy health information effect, which is an herbal derived... If you experience any adverse reactions milk thistle and cymbalta intended to be a potent inhibitor for enzymes responsible for,... Add it to skin creams effect, which is a standardized preparation extracted from the mature fruit Silybum...